کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10227895 | 465 | 2014 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
VEGF-binding aptides and the inhibition of choroidal and retinal neovascularization
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کلمات کلیدی
Choroidal neovascularization - neovascularization choroidalretinal neovascularization - neovascularization شبکیهPathological angiogenesis - آنژیوژنز پاتولوژیکdiabetic retinopathy - رتینوپاتی دیابتیage-related macular degeneration - سن تخریب ماکولا مربوط به سن استVascular endothelial growth factor - فاکتور رشد اندوتلیال عروقی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: VEGF-binding aptides and the inhibition of choroidal and retinal neovascularization VEGF-binding aptides and the inhibition of choroidal and retinal neovascularization](/preview/png/10227895.png)
چکیده انگلیسی
Age-related macular degeneration and diabetic retinopathy are leading causes of blindness. Vascular endothelial growth factor (VEGF) is known to be the main factor that induces pathological angiogenesis in these diseases. In this study, we investigate the therapeutic potential and safety profiles of high-affinity peptides targeting VEGF which are identified using an 'aptide' technology. We show that two VEGF-binding aptides, APTVEGF1 and APTVEGF2, demonstrate high binding affinity and specificity to VEGF. Furthermore, they suppress VEGF-induced activation of VEGF receptor-2, in vitro angiogenesis, and in vivo pathological choroidal and retinal neovascularization. Despite potent anti-angiogenic effects, both VEGF-binding aptides do not induce any definite toxicity at the level of cellular viability, histological integrity, and gene expression. Our data show the therapeutic potential of VEGF-binding peptides for the treatment of choroidal and retinal neovascularization.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomaterials - Volume 35, Issue 9, March 2014, Pages 3052-3059
Journal: Biomaterials - Volume 35, Issue 9, March 2014, Pages 3052-3059
نویسندگان
Dong Hyun Jo, Sunghyun Kim, Daejin Kim, Jin Hyoung Kim, Sangyong Jon, Jeong Hun Kim,