کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10229192 509 2013 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Nanoparticle diffusion in respiratory mucus from humans without lung disease
ترجمه فارسی عنوان
انتشار نانوذرات در مخاط های تنفسی از انسان بدون بیماری ریه
کلمات کلیدی
نانوذرات استنشاقی، مخاط دهان، ذرات نفوذی مخاطی، ردیابی ذرات چندگانه، رئوئولوژی،
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
چکیده انگلیسی
A major role of respiratory mucus is to trap inhaled particles, including pathogens and environmental particulates, to limit body exposure. Despite the tremendous health implications, how particle size and surface chemistry affect mobility in respiratory mucus from humans without lung disease is not known. We prepared polymeric nanoparticles densely coated with low molecular weight polyethylene glycol (PEG) to minimize muco-adhesion, and compared their transport to that of uncoated particles in human respiratory mucus, which we collected from the endotracheal tubes of surgical patients with no respiratory comorbidities. We found that 100 and 200 nm diameter PEG-coated particles rapidly penetrated respiratory mucus, at rates exceeding their uncoated counterparts by approximately 15- and 35-fold, respectively. In contrast, PEG-coated particles ≥500 nm in diameter were sterically immobilized by the mucus mesh. Thus, even though respiratory mucus is a viscoelastic solid at the macroscopic level (as measured using a bulk rheometer), nanoparticles that are sufficiently small and muco-inert can penetrate the mucus as if it were primarily a viscous liquid. These findings help elucidate the barrier properties of respiratory mucus and provide design criteria for therapeutic nanoparticles capable of penetrating mucus to approach the underlying airway epithelium.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomaterials - Volume 34, Issue 13, April 2013, Pages 3439-3446
نویسندگان
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