کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10229249 | 515 | 2012 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Long-term multimodal imaging of tumor draining sentinel lymph nodes using mesoporous silica-based nanoprobes
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
Magnetic resonance imaging - تصویربرداری رزونانس مغناطیسیNear-infrared fluorescence imaging - تصویربرداری فلورسنت نزدیکی مادون قرمزMultimodality imaging - تصویربرداری چندمتغیریPositron emission tomography - توموگرافی گسیل پوزیترونTumor metastasis - متاستاز تومورMesoporous silica nanoparticles - نانوذرات سیلیسیم Mesoporous
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The imaging of sentinel lymph nodes (SLNs), the first defense against primary tumor metastasis, has been considered as an important strategy for noninvasive tracking tumor metastasis in clinics. In this study, we report the development and application of mesoporous silica-based triple-modal nanoprobes that integrate multiple functional moieties to facilitate near-infrared optical, magnetic resonance (MR) and positron emission tomography (PET) imaging. After embedding near-infrared dye ZW800, the nanoprobe was labeled with T1 contrast agent Gd3+ and radionuclide 64Cu through chelating reactions. High stability and long intracellular retention time of the nanoprobes was confirmed by in vitro characterization, which facilitate long-term in vivo imaging. Longitudinal multimodal imaging was subsequently achieved to visualize tumor draining SLNs up to 3 weeks in a 4T1 tumor metastatic model. Obvious differences in uptake rate, amount of particles, and contrast between metastatic and contra-lateral sentinel lymph nodes were observed. These findings provide very helpful guidance for the design of robust multifunctional nanomaterials in SLNs' mapping and tumor metastasis diagnosis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomaterials - Volume 33, Issue 17, June 2012, Pages 4370-4378
Journal: Biomaterials - Volume 33, Issue 17, June 2012, Pages 4370-4378
نویسندگان
Xinglu Huang, Fan Zhang, Seulki Lee, Magdalena Swierczewska, Dale O. Kiesewetter, Lixin Lang, Guofeng Zhang, Lei Zhu, Haokao Gao, Hak Soo Choi, Gang Niu, Xiaoyuan Chen,