کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10229692 | 546 | 2011 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Multifunctional silica nanotubes for dual-modality gene delivery and MR imaging
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Multifunctional silica nanotubes for dual-modality gene delivery and MR imaging Multifunctional silica nanotubes for dual-modality gene delivery and MR imaging](/preview/png/10229692.png)
چکیده انگلیسی
This work demonstrated the development of multifunctional silica nanotubes (SNT) by functionalization of their inner void and outer surface with magnetic-fluorescence nanocomposites and cationic polymers, respectively. The successful construction of BPEI-SNT was established by electron energy loss spectroscopy in conjugation with standard analytical tools. The mean fluorescence intensity in a FACS assay, a luciferase gene expression assay and a confocal fluorescence study demonstrated the efficacy of BPEI-SNT as a gene delivery vector. Endocytotic uptake was also demonstrated by the colocalization of LysoTracker Red® and green fluorescent quantum dots. Moreover, enhanced magnetic resonance imaging revealed the potential of the BPEI-SNT nanocomposite to act as a dual-modality nano-device.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomaterials - Volume 32, Issue 11, April 2011, Pages 3042-3052
Journal: Biomaterials - Volume 32, Issue 11, April 2011, Pages 3042-3052
نویسندگان
Ran Namgung, Yuhai Zhang, Qi Ling Fang, Kaushik Singha, Hwa Jeong Lee, Il Keun Kwon, Yong Yeon Jeong, In-Kyu Park, Sang Jun Son, Won Jong Kim,