کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10230051 673 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Randomly oriented, upright SiO2 coated nanorods for reduced adhesion of mammalian cells
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
Randomly oriented, upright SiO2 coated nanorods for reduced adhesion of mammalian cells
چکیده انگلیسی
Cell interactions with nanostructures are of broad interest because of applications in controlling tissue response to biomedical implants. Here we show that dense and upright SiO2 coated nanorods nearly eliminate cell adhesion in fibroblasts and endothelial cells. The lack of adhesion is not due to a decrease in matrix protein adsorption on the nanostructures, but rather an inability of cells to assemble focal adhesions. Using spatially patterned nanorods, we show that cells display a preference for flat regions of the surface. Our results support a model in which interfering with nanoscale spacing of ligated integrins results in reduced cell adhesion and subsequent cell death. We propose that dense monolayers of nanorods are a promising nanotechnology for preventing mammalian cell fouling of biomaterials.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomaterials - Volume 30, Issue 27, September 2009, Pages 4488-4493
نویسندگان
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