کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10230204 | 774 | 2005 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Fiber-based tissue-engineered scaffold for ligament replacement: design considerations and in vitro evaluation
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Fiber-based tissue-engineered scaffold for ligament replacement: design considerations and in vitro evaluation Fiber-based tissue-engineered scaffold for ligament replacement: design considerations and in vitro evaluation](/preview/png/10230204.png)
چکیده انگلیسی
The anterior cruciate ligament (ACL) is the major intraarticular ligamentous structure of the knee, which functions as a joint stabilizer. It is the most commonly injured ligament of the knee, with over 150,000 ACL surgeries performed annually in the United States. Due to limitations associated with current grafts for ACL reconstruction, there is a significant demand for alternative graft systems. We report here the development of a biodegradable, tissue-engineered ACL graft. Several design parameters including construct architecture, porosity, degradability, and cell source were examined. This graft system is based on polymeric fibers of polylactide-co-glycolide 10:90, and it was fabricated using a novel, three-dimensional braiding technology. The resultant micro-porous scaffold exhibited optimal pore diameters (175-233 μm) for ligament tissue ingrowth, and initial mechanical properties of the construct approximate those of the native ligament.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomaterials - Volume 26, Issue 13, May 2005, Pages 1523-1532
Journal: Biomaterials - Volume 26, Issue 13, May 2005, Pages 1523-1532
نویسندگان
James A. Cooper, Helen H. Lu, Frank K. Ko, Joseph W. Freeman, Cato T. Laurencin,