کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10230320 | 801 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Microspheres of corn protein, zein, for an ivermectin drug delivery system
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کلمات کلیدی
PLA, poly(lactic acid)IVM, ivermectin - IVM، IvermectinPLGA, poly(lactic-co-glycolic acid) - PLGA، پلی (اسید لاکتیک-کل گلیکولیک)SEM, scanning electron microscope - SEM، میکروسکوپ الکترونی اسکنControlled drug release - آزادی کنترل داروییBiodegradation - تجزیه زیستیDrug delivery - تحویل(رهایش) داروMicrospheres - میکروسپرسElectron microscopy - میکروسکوپ الکترونی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
A novel microsphere drug delivery system of ivermectin (IVM) using hydrophobic protein zein was prepared by the phase separation method and characterized by a scanning electron microscope and laser light scattering particle size analyzer. Releases of model drug IVM from zein microspheres, tabletted microspheres and pepsin degradation of tabletted microspheres were also performed in vitro to investigate the mechanism of model drug release. The results show that the zein microspheres and tabletted microspheres are suitable for use as a sustained-release form of IVM. The microspheres may also be useful in drug targeting system since the diameter of the microspheres is appropriate for phagocytosis by macrophages. Moreover, the release of IVM from enzymatic degraded tabletted microspheres shows a zero-order release, implying a potential application in tissue engineering for preparing scaffold, which is composed of microspheres encapsulating bioactive components for stimulating cell differentiation and proliferation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomaterials - Volume 26, Issue 1, January 2005, Pages 109-115
Journal: Biomaterials - Volume 26, Issue 1, January 2005, Pages 109-115
نویسندگان
Xinming Liu, Qingshen Sun, Huajie Wang, Lei Zhang, Jin-Ye Wang,