کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10234370 43075 2005 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Design and In-vitro Testing of Effective Poly(l-Lysine Iso-Phthalamide) Based Drug Targeting Systems for Solid Tumours
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
Design and In-vitro Testing of Effective Poly(l-Lysine Iso-Phthalamide) Based Drug Targeting Systems for Solid Tumours
چکیده انگلیسی
The mode of cell uptake, relative cytotoxicity and efficacy of poly (l-lysine iso-phthalamide)-drug conjugates, PEG-graft poly (l-lysine iso-phthalamide)-drug containing micelles, poly (l-lysine iso-phthalamide) modified drug/protein nanospheres and unmodified protein nanospheres as potential delivery systems have been evaluated using doxorubicin and polymethine fluorophores as model drugs. pH dependent cell membrane lysis has been demonstrated using a haemolysis model and the cytotoxicity of the polymeric system evaluated using standard MTT and LDH activity assays. In-vitro toxicity and cellular targeting data are presented and the potential healthcare impact of such systems is discussed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Bioproducts Processing - Volume 83, Issue 2, June 2005, Pages 141-146
نویسندگان
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