The effects of negative pressure treatment on the extracellular matrix gene expression and protein production of fibroblasts

- Negative pressure wound therapy has been suggested for wounds management.
- Periodical NP upregulate Collagen I, III, and fibronectin mRNA in mouse fibroblasts.
- TGF-β1 protein production was enhanced, but not TIMP-1, pro-MMP-9, decorin, or IL-6.
- Negative pressure regulates extracellular matrix production in mouse fibroblasts.