Investigation of a self-assembling microgel containing an (S)-propranolol molecularly imprinted polymer in a native tissue microenvironment: Part I. Preparation and characterization

- We synthesized the hierarchical microporous MIP selective for (S)-propranolol.
- A microgel-MIP composed of a mixed crosslinker afforded high enantioselectivity.
- MIP binding site precisely fine-tuned expression of mRNA from DNA in animal.
- (S)-propranolol induced activation of mitochondrial apoptosis and self-renewal.
- Imprinting of chemical shapes provides insight in phenomena in cell biology.