The simultaneous production of single-cell protein and a recombinant antibacterial peptide by expression of an antibacterial peptide gene in Yarrowia lipolytica

► The DNA fragment encoding the N-terminus of scallop H2A was expressed in the marine derived Yarrowia lipolytica. ► The transformant 29a had the antibacterial activity against Vibrio spp and high protein content. ► The molecular mass of the recombinant antibacterial peptide was 4.5 kDa. ► The purified recombinant antibacterial peptide could cause leakage of the bacteria.