Production of a key chiral intermediate of Betahistine with a newly isolated Kluyveromyces sp. in an aqueous two-phase system

► First report on microbial production of Betahistine intermediate (S)-CPMA. ► Isolation of Kluyveromyces sp. strain for the asymmetric reduction of CPMK. ► Improved substrate tolerance and biocompatibility in aqueous two-phase system.