Scaling-up of a B-phycoerythrin production and purification bioprocess involving aqueous two-phase systems: Practical experiences

► A detailed study describing the scaling up of an ATPS process from bench scale to pilot plant is described. ► Production and recovery of highly purified B-phycoerythrin (BPE) at pilot plant level is reported. ► Experiences derived from a bioprocess scale-up (850×) are documented.