کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10235876 45063 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mutation breeding of Emericella foeniculicola TR21 for improved production of tanshinone IIA
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
Mutation breeding of Emericella foeniculicola TR21 for improved production of tanshinone IIA
چکیده انگلیسی
TR21, an original tanshinone IIA-producing endophytic fungus from the root of Salvia miltiorrhiza Bunge, produces low levels of tanshinone IIA. Three techniques were used to rapidly improve tanshinone IIA production: TR21 mutation by ultraviolet radiation (UV), TR21 mutation by sodium nitrite (NaNO2) and TR21 mutation by a combination of both UV and NaNO2. An improved mutant, labeled as NU152, was obtained from the combination of UV and NaNO2. The content of tanshinone IIA produced by NU152 held a relative high value of 51.44 ± 0.22 μg per g, and the NU152 produced a more than 1.46-fold increase in tanshinone IIA yield, compared with the wild type TR21 (P < 0.05). The fungus NU152 showed a possible way for the sustainable production of tanshinone IIA.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Process Biochemistry - Volume 46, Issue 10, October 2011, Pages 2059-2063
نویسندگان
, , ,