کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10236334 45143 2005 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Age-related changes in antioxidant status and oxidative damage to lipids and dna in mitochondria of rat liver
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
Age-related changes in antioxidant status and oxidative damage to lipids and dna in mitochondria of rat liver
چکیده انگلیسی
To investigate the correlation between oxidative stress and mitochondrial damage with aging, antioxidant system, levels of oxidative DNA damage and as an index of the loss of plasma membrane integrity lipid peroxidation and membrane potential were studied. Results showed that the activities of antioxidant enzymes superoxide dismutase (SOD) and catalase significantly decreased during aging, however glutathione peroxidase (GSH-PX) increased in the aged mitochondria and glutathione (GSH) did not change during aging. No statistical difference was observed in the lipid peroxidation of mitochondria between young and old animals. The level of oxidative DNA damage (measured as 8oxo-dG) tended to increase during aging.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Process Biochemistry - Volume 40, Issue 2, February 2005, Pages 903-908
نویسندگان
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