کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10236334 | 45143 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Age-related changes in antioxidant status and oxidative damage to lipids and dna in mitochondria of rat liver
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
بیو مهندسی (مهندسی زیستی)
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چکیده انگلیسی
To investigate the correlation between oxidative stress and mitochondrial damage with aging, antioxidant system, levels of oxidative DNA damage and as an index of the loss of plasma membrane integrity lipid peroxidation and membrane potential were studied. Results showed that the activities of antioxidant enzymes superoxide dismutase (SOD) and catalase significantly decreased during aging, however glutathione peroxidase (GSH-PX) increased in the aged mitochondria and glutathione (GSH) did not change during aging. No statistical difference was observed in the lipid peroxidation of mitochondria between young and old animals. The level of oxidative DNA damage (measured as 8oxo-dG) tended to increase during aging.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Process Biochemistry - Volume 40, Issue 2, February 2005, Pages 903-908
Journal: Process Biochemistry - Volume 40, Issue 2, February 2005, Pages 903-908
نویسندگان
V. Valls, C. Peiro, P. Muñiz, G.T. Saez,