Towards continuous sustainable processes for enzymatic synthesis of biodiesel in hydrophobic ionic liquids/supercritical carbon dioxide biphasic systems

► Hydrophobic ILs containing large alkyl chains dissolves both triolein and methanol. ► Enzymatic synthesis of biodiesel in ILs improves by increasing hydrophobicity of ions. ► Continuous enzymatic synthesis of biodiesel is carried out in ILs/scCO2 biphasic media. ► [Bmim][PF6] protects biocatalysts during continuous synthesis of biodiesel in scCO2.