کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10305608 | 546972 | 2015 | 28 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Gray matter volumes in patients with bipolar disorder and their first-degree relatives
ترجمه فارسی عنوان
حجم های خاکستری در بیماران مبتلا به اختلال دوقطبی و بستگان درجه اول آنها
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
چکیده انگلیسی
Bipolar disorder (BD) is highly heritable. First-degree relatives of BD patient have an increased risk to develop the disease. We investigated abnormalities in gray matter (GM) volumes in healthy first-degree relatives of BD patients to identify possible brain structural endophenotypes for the disorder. 3D T1-weighted magnetic resonance images were obtained from 25Â DSM-IV BD type I patients, 23 unaffected relatives, and 27 healthy controls (HC). A voxel-based morphometry protocol was used to compare differences in GM volumes between groups. BD patients presented reduced GM volumes bilaterally in the thalamus compared with HC. Relatives presented no global or regional GM differences compared with HC. Our negative results do not support the role of GM volume abnormalities as endophenotypes for BD. Thalamic volume abnormalities may be associated the pathophysiology of the disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychiatry Research: Neuroimaging - Volume 234, Issue 2, 30 November 2015, Pages 188-193
Journal: Psychiatry Research: Neuroimaging - Volume 234, Issue 2, 30 November 2015, Pages 188-193
نویسندگان
Fabiano G. Nery, Alexandre Duarte Gigante, Jose A. Amaral, Francy B.F. Fernandes, Mariangeles Berutti, Karla M. Almeida, Camila de Godoi Carneiro, Fabio Luis Souza Duran, Maria G. Otaduy, Claudia Costa Leite, Geraldo Busatto, Beny Lafer,