کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10305689 | 546995 | 2013 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cortical and subcortical volumes in adolescents with alcohol dependence but without substance or psychiatric comorbidities
ترجمه فارسی عنوان
حجم کورتیکال و غیر کورتیک در نوجوانان با وابستگی به الکل، اما بدون وجود مواد مخدر یا همراهی با روانپزشکی
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کلمات کلیدی
تصویربرداری رزونانس مغناطیسی، مورفومتری مبتنی بر وکسل، آفریقای جنوبی،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
چکیده انگلیسی
Most prior studies of the effects of excessive alcohol intake on the adolescent brain examined alcohol-use-dependent samples with comorbid psychiatric and substance use disorders. In the Cape Town region, we identified a sizeable cohort of adolescents with alcohol use disorders (AUD) without externalizing or other psychiatric disorders. We examined brain morphology in 64 such adolescents compared to age- and gender-matched healthy controls. Magnetic resonance imaging data were analyzed using FSL's FIRST software for subcortical volumes, and cortical gray matter (GM) was analyzed using voxel-based morphometry (VBM) and regions of interest (ROI) analysis. AUD boys had smaller thalamic and putamen volumes compared to non-drinking boys, while AUD girls had larger thalamic and putamen volumes compared to non-drinking girls. VBM revealed a large region of decreased GM density in AUDs compared to controls located in the left lateral frontal, temporal, and parietal lobes, extending medially deep into the parietal lobe. Smaller GM volume in this region was also present when examined using ROI analysis. Our lack of findings in other brain regions, particularly the hippocampus, suggests that reports of smaller brain volumes in adolescent AUDs in the literature are a consequence of psychiatric and substance abuse comorbidities.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychiatry Research: Neuroimaging - Volume 214, Issue 1, 30 October 2013, Pages 1-8
Journal: Psychiatry Research: Neuroimaging - Volume 214, Issue 1, 30 October 2013, Pages 1-8
نویسندگان
George Fein, David Greenstein, Valerie A. Cardenas, Natalie L. Cuzen, Jean-Paul Fouche, Helen Ferrett, Keven Thomas, Dan J. Stein,