کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10317242 | 621904 | 2014 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Association of dopamine gene variants, emotion dysregulation and ADHD in autism spectrum disorder
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Association of dopamine gene variants, emotion dysregulation and ADHD in autism spectrum disorder Association of dopamine gene variants, emotion dysregulation and ADHD in autism spectrum disorder](/preview/png/10317242.png)
چکیده انگلیسی
The aim of the present study was to evaluate the association of dopaminergic gene variants with emotion dysregulation (EMD) and attention-deficit/hyperactivity disorder (ADHD) symptoms in children with autism spectrum disorder (ASD). Three dopamine transporter gene (SLC6A3/DAT1) polymorphisms (intron8 5/6 VNTR, 3â²-UTR 9/10 VNTR, rs27072 in the 3â²-UTR) and one dopamine D2 receptor gene (DRD2) variant (rs2283265) were selected for genotyping based on à priori evidence of regulatory activity or, in the case of DAT1 9/10 VNTR, commonly reported associations with ADHD. A sample of 110 children with ASD was assessed with a rigorously validated DSM-IV-referenced rating scale. Global EMD severity (parents' ratings) was associated with DAT1 intron8 (ηp2 = .063) and rs2283265 (ηp2 = .044). Findings for DAT1 intron8 were also significant for two EMD subscales, generalized anxiety (ηp2 = .065) and depression (ηp2 = .059), and for DRD2 rs2283265, depression (ηp2 = .053). DRD2 rs2283265 was associated with teachers' global ratings of ADHD (ηp2 = .052). DAT1 intron8 was associated with parent-rated hyperactivity (ηp2 = .045) and both DAT1 9/10 VNTR (ηp2 = .105) and DRD2 rs2283265 (ηp2 = .069) were associated with teacher-rated inattention. These findings suggest that dopaminergic gene polymorphisms may modulate EMD and ADHD symptoms in children with ASD but require replication with larger independent samples.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Research in Developmental Disabilities - Volume 35, Issue 7, July 2014, Pages 1658-1665
Journal: Research in Developmental Disabilities - Volume 35, Issue 7, July 2014, Pages 1658-1665
نویسندگان
Kenneth D. Gadow, Julia K. Pinsonneault, Greg Perlman, Wolfgang Sadee,