کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1036298 | 943881 | 2011 | 5 صفحه PDF | دانلود رایگان |
We report here ancient mycobacterial protein analysis of paleoanthropological findings, from Hungarian archaeological sites. These proteomic results, the oldest reported pathological protein sequences which were extracted and analyzed by matrix-assisted laser desorption/ionization tandem time-of-flight mass spectrometry (MALDI TOF/TOF MS). Through a combination of direct sequencing and peptide mass fingerprinting (PMF) several mycobacterial protein (adenylate kinase, catalase-peroxidase-peroxinitritase-T katG, dehydrogenase/reductase, fumarate reductase flavoprotein subunit, glycosyl transferase, LysR family transcriptional regulator protein, oxidoreductase, putative helicase, translation initiation factor IF-2 protein, peptide sythetase nrp) have been identified. The ancient mycobacterial proteins and their sequences have the potential to expand our understanding of the prehistoric epidemiology and evolution of these pathogens.
Journal: Journal of Archaeological Science - Volume 38, Issue 1, January 2011, Pages 197–201