کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10375059 | 880035 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cardanol as a replacement for cholesterol into the lipid bilayer of POPC liposomes
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موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
شیمی کلوئیدی و سطحی
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چکیده انگلیسی
Large unilamellar liposomes were prepared by hydration of 1-palmitoyl-2-oleylphosphatydilcholine (POPC) films and subsequent extrusion of the obtained liposomal suspension. Inclusion of cholesterol and cardanol brings about a stabilization of the membranes of the liposomes, as determined by their rates of release of entrapped 5(6)-carboxyfluorescein. The liposome breakdown was promoted by a non-ionic surfactant (Triton X-100) and the kinetic measurements were carried out by fluorimetry in water at 25 °C. Morphological analyses of giant POPC liposomes in the presence and in the absence of both guests were also performed. The results obtained suggest the use of cardanol (an easy available natural product) as a replacement for cholesterol as a new possibility for stabilizing liposomes in drug targetting.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Colloids and Surfaces B: Biointerfaces - Volume 40, Issue 1, 15 January 2005, Pages 11-18
Journal: Colloids and Surfaces B: Biointerfaces - Volume 40, Issue 1, 15 January 2005, Pages 11-18
نویسندگان
Paolo De Maria, Paolino Filippone, Antonella Fontana, Carla Gasbarri, Gabriella Siani, Diana Velluto,