Fluid dynamics modeling for synchronizing surface plasmon resonance and quartz crystal microbalance as tools for biomolecular and targeted drug delivery studies

► CFD determines that flow in SPR and QCM flow cells is in the stokes flow regime. ► This allows for the development of a scaling expression. ► Through scaling expression, the two devices can be synchronized for combined use. ► Test 1: biomolecular interaction system of surface immobilized biotin and streptavidin. ► Test 2: biotinylated liposomes interacting with a streptavidin functionalized surface.