کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10382 683 2009 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The influence of poly(ethylene oxide) grafting via siloxane tethers on protein adsorption
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
The influence of poly(ethylene oxide) grafting via siloxane tethers on protein adsorption
چکیده انگلیسی

Amphiphilic PEO–silanes (a–c) having siloxane tethers of varying lengths with the general formula α-(EtO)3Si–(CH2)2–oligodimethylsiloxanen-block-poly(ethylene oxide)8–OCH3 [n = 0 (a), n = 4 (b), and n = 13 (c)] were grafted onto silicon wafers and resistance to adsorption of plasma proteins was measured. Distancing the PEO segment from the hydrolyzable triethoxysilane [(EtO)3Si] grafting group by a oligodimethylsiloxane tether represents a new method of grafting PEO chains to surfaces. Properties of surfaces grafted with a–c were compared to surfaces grafted with a traditional PEO–silane containing a propyl spacer [(EtO)3Si–(CH2)3–poly(ethylene oxide)8–OCH3, PEO control]. As the siloxane tether length increased, chain density of PEO–silanes grafted onto oxidized silicon wafers decreased and hydrophobicity of the PEO–silane increased which led to a decrease in surface hydrophilicity. Despite decreased surface hydrophilicity, resistance to the adsorption of bovine serum albumin (BSA) increased in the order: PEO control < a < b ≈ c and to human fibrinogen (HF) increased in the order: PEO control < a < b < c.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomaterials - Volume 30, Issue 13, May 2009, Pages 2433–2439
نویسندگان
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