کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10385207 | 882578 | 2005 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Monitoring of Multiphase Pharmaceutical Processes Using Electrical Resistance Tomography
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
تصفیه و جداسازی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Recent developments in the use of non-intrusive, electrical measurements to interrogate mixing processes in batch vessels have triggered a joint GSK/Imperial College London project aimed at assessing the applicability of electrical resistance tomography (ERT) to pharmaceutical chemical development. Several vessel/stirrer configurations designed to mimic typical plant reactor geometries were investigated in connection with multiphase processes typical of the pharmaceutical industry. Case studies related to liquid-liquid dispersion and solids suspension in stirred tanks are described and the data obtained are compared with on-line monitoring information as well as computational fluid dynamics modeling results. Overall, very encouraging results were achieved for model and industrial processes. This approach shows promise for on-line control of process mixing performance as well as efficiency evaluation and optimization of several reactor geometries. This allows us to conclude that ERT is a valuable tool for the development of robust active pharmaceutical ingredient (API) manufacturing processes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemical Engineering Research and Design - Volume 83, Issue 7, July 2005, Pages 794-805
Journal: Chemical Engineering Research and Design - Volume 83, Issue 7, July 2005, Pages 794-805
نویسندگان
F. Ricard, C. Brechtelsbauer, X.Y. Xu, C.J. Lawrence,