Co-solubilization of Lamotrigine by Complexation and Micellization in Binary Solvent Mixtures

• The effect of β-CD, SLS and PEG on the solubilization of Lamotrigine was studied.
• Applications of all solubilizing agents lead to an improvement in drug solubility.
• Micellization and complexation show synergistic effect on drug solubility.
• Experimental solubility data were fitted to Jouyban-Acree model.
• Excellent agreement was obtained between experimental and calculated data.

The present work was carried out with the purpose of evaluating the effect of β-cyclodextrin (β-CD), sodium lauryl sulfate (SLS) and polyethylene glycol 200 (PEG 200) on the solubilization of lamotrigine by means of phase-solublility studies and solubility prediction using Jouyban-Acree model.The experimental solubility values of various mixtures were fitted to the equation and fitting accuracy of solubility data to this model was evaluated. A quantitative relationship between the solubilizing agents was assessed and the predictive accuracy of the Jouyban-Acree model and its applicability assuring reliable prediction of the model in binary systems was studied. The significance of the simultaneous presence of SLS and β-CD on lamotrigine solubility was studied in binary solvent mixture.

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