A novel ultrasensitive aptasensor based on silver nanoparticles measured via enhanced voltammetric response of electrochemical reduction of riboflavin as redox probe for cocaine detection

- The aptasensor is constructed by covalent immobilization of aptamer-functionalized AgNPs on the MWCNTs/IL/Chit nanocomposite as the sensing interface.
- Riboflavin (RF) has been used for the first time as the probe redox in the development of the electrochemical aptasensor for the diagnosis of cocaine.
- AgNPs lead to the acceleration of the electron transfer kinetics related to the reduction of RF.
- The aptasensor showed high sensitivity and selectivity.
- Linear range from 2 nM to 2500 nM with LOD of 150 pM for cocaine detection.