کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10431765 910226 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Multi-scale analysis of optic chiasmal compression by finite element modelling
ترجمه فارسی عنوان
تجزیه و تحلیل چند بعدی فشرده سازی فیزیکی نوری با مدل سازی عناصر محدود
موضوعات مرتبط
مهندسی و علوم پایه سایر رشته های مهندسی مهندسی پزشکی
چکیده انگلیسی
The precise mechanism of bitemporal hemianopia (a type of partial visual field defect) is still not clear. Previous work has investigated this problem by studying the biomechanics of chiasmal compression caused by a pituitary tumour growing up from below the optic chiasm. A multi-scale analysis was performed using finite element models to examine both the macro-scale behaviour of the chiasm and the micro-scale interactions of the nerve fibres within it using representative volume elements. Possible effects of large deflection and non-linear material properties were incorporated. Strain distributions in the optic chiasm and optic nerve fibres were obtained from these models. The results of the chiasmal model agreed well with the limited experimental results available, indicating that the finite element modelling can be a useful tool for analysing chiasmal compression. Simulation results showed that the strain distribution in nasal (crossed) nerve fibres was much more nonuniform and locally higher than in temporal (uncrossed) nerve fibres. This strain difference between nasal and temporal nerve fibres may account for the phenomenon of bitemporal hemianopia.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Biomechanics - Volume 47, Issue 10, 18 July 2014, Pages 2292-2299
نویسندگان
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