کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10432381 | 910246 | 2012 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Modeling of cardiac muscle thin films: Pre-stretch, passive and active behavior
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
سایر رشته های مهندسی
مهندسی پزشکی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Modeling of cardiac muscle thin films: Pre-stretch, passive and active behavior Modeling of cardiac muscle thin films: Pre-stretch, passive and active behavior](/preview/png/10432381.png)
چکیده انگلیسی
Recent progress in tissue engineering has made it possible to build contractile bio-hybrid materials that undergo conformational changes by growing a layer of cardiac muscle on elastic polymeric membranes. Further development of such muscular thin films for building actuators and powering devices requires exploring several design parameters, which include the alignment of the cardiac myocytes and the thickness/Young's modulus of elastomeric film. To more efficiently explore these design parameters, we propose a 3-D phenomenological constitutive model, which accounts for both the passive deformation including pre-stretch and the active behavior of the cardiomyocytes. The proposed 3-D constitutive model is implemented within a finite element framework, and can be used to improve the current design of bio-hybrid thin films and help developing bio-hybrid constructs capable of complex conformational changes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Biomechanics - Volume 45, Issue 5, 15 March 2012, Pages 832-841
Journal: Journal of Biomechanics - Volume 45, Issue 5, 15 March 2012, Pages 832-841
نویسندگان
Jongmin Shim, Anna Grosberg, Janna C. Nawroth, Kevin Kit Parker, Katia Bertoldi,