کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10433268 910285 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Sickle cell trait human erythrocytes are significantly stiffer than normal
موضوعات مرتبط
مهندسی و علوم پایه سایر رشته های مهندسی مهندسی پزشکی
پیش نمایش صفحه اول مقاله
Sickle cell trait human erythrocytes are significantly stiffer than normal
چکیده انگلیسی
Atomic force microscopy (AFM) allows for high-resolution topography studies of biological cells and measurement of their mechanical properties in physiological conditions. In this work, AFM was employed to measure the stiffness of abnormal human red blood cells from human subjects with the genotype for sickle cell trait. The determined Young's modulus was compared with that obtained from measurements of erythrocytes from healthy subjects. The results showed that Young's modulus of pathological erythrocytes was approximately three times higher than in normal cells. Observed differences indicate the effect of the polymerization of sickle hemoglobin as well as possible changes in the organization of the cell cytoskeleton associated with the sickle cell trait.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Biomechanics - Volume 44, Issue 4, 24 February 2011, Pages 657-661
نویسندگان
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