Catanionic lipid nanosystems improve pharmacokinetics and anti-lung cancer activity of curcumin

A class of novel catanionic lipid nanosystems loaded with CCM (CCM-CLNs) was developed for the efficient delivery of CCM. Compared with free CCM, CCM-CLNs exhibited significant improvements in pharmacokinetics and bioavailability, as well as a substantial increase in anti-lung cancer activity. This is the first report of induction of apoptosis in LLC cells by CCM through the PI3K/Akt/FoxO1/Bim signaling pathway. Catanionic lipid nanocarriers show promise for the therapeutic delivery of insoluble anti-tumor drugs.388