RGD peptide-conjugated selenium nanoparticles: antiangiogenesis by suppressing VEGF-VEGFR2-ERK/AKT pathway

Herein we described the synthesis of RGD peptide-decorated and doxorubicin-loaded selenium nanoparticles (RGD-NPs) that could target tumor vasculature to enhance the cellular uptake and antiangiogenic activities in vitro and in vivo. The nanosystem could also inhibit angiogenesis through induction of apoptosis and cell cycle arrest in HUVECs via suppression of VEGF-VEGFR2-ERK/AKT signaling axis by triggering ROS-mediated DNA damage, and suppress MCF-7 tumor growth and angiogenesis in nude mice model.150