Arginine-rich ionic complementary peptides as potential drug carriers: Impact of peptide sequence on size, shape and cell specificity

The graphical abstract includes a proposed mechanism of the formulation of self-assembling peptides with ellipticine (EPT), which explains the different nanoparticle morphologies shown in AFM images. Colors represent the properties of the amino acid side chains, such as hydrophobicity, positive or negative charges. Green symbols represent EPT. The cytotoxicity results (plots on the right) demonstrate the shape and amino acid arrangement effects on the cell specificity of peptide-EPT complexes.256