Polyanionic carbosilane dendrimer-conjugated antiviral drugs as efficient microbicides: Recent trends and developments in HIV treatment/therapy

(A) Schematic view of early stages of the HIV-1 replication cycle before integration process: binding, fusion and uncoating and reverse-transcription. (B) Enhanced anti-HIV-1 activity by bitherapy with polyanionic carbosilane dendrimers and maraviroc. (C) Complementary and cooperative microbicidal activity of dendrimer/maraviroc/tenofovir combination due to dendrimer and maraviroc is targeted to earlier stages of HIV-1 replication cycle, virus entry and fusion, while tenofovir acts on later stages of HIV-1 entry, reverse-transcription. (D) Binding of gp120 to dendrimer through multivalent interactions to prevent the HIV-1 entry to the host cell.202