Ultrasound-responsive microbubbles for sonography-guided siRNA delivery

An siRNA-encapsulated US-responsive agent, which was developed from polymeric siRNA micelles and liposomal MBs using hetero-assembling strategy, was exposed by low-frequency US at the tumor site after intratumoral injection, leading to enhanced permeability of tumor tissues for much more effective delivery of siRNA into deep tumor regions and good therapeutic effect.124