Magnetic field-guided cell delivery with nanoparticle-loaded human corneal endothelial cells

One of the main challenges in cell therapy is the targeting of the cells to the right place. We assessed the effect of adding magnetic nanoparticles (MNPs) to human corneal endothelial cells (HCECs) in culture. In the presence of a magnetic field, MNP-loaded HCEC delivered cell density increased 2.4-fold compared to gravity alone. We also found no short- or long-term changes in cell viability and identity, or in HCECs' ability to form a tight, functional monolayer. Thus, nanoparticle-mediated cell delivery may be a viable solution for corneal cell therapy.54