Transferrin-modified liposome promotes α-mangostin to penetrate the blood-brain barrier

Representative schematic of α-M liposome modified with transferrin for brain targeting. First, the α-M liposome was modified with transferrin to prepare the Tf(α-M) liposome. After investigation of the intracellular liposome distribution and transport across the BBB in vitro, the liposome was injected into the rats via the tail vein. The Tf(α-M) liposome was transported across the BBB via the receptor-mediated endocytosis pathway. Finally, the improvement of brain delivery of α-M was measured.119