The hunt for brain Aβ oligomers by peripherally circulating multi-functional nanoparticles: Potential therapeutic approach for Alzheimer disease

The most culprit Aβ assemblies, soluble Aβ oligomers, are in equilibrium between the brain and the blood across the blood-brain barrier. Impairment in the clearance of Aβ from the brain, that promotes its aggregation to plaques, has been suggested to contribute to the onset/progression of Alzheimer disease. A therapeutic strategy based on sequestering peripheral soluble Aβ assemblies by using multi-functional nanoparticles may draw out Aβ excess from the brain and from the cerebral blood vessel via sink effect.266