Shape regulated anticancer activities and systematic toxicities of drug nanocrystals in vivo

Shape regulated anticancer activities and systematic toxicities of hydroxycamptothecin nanorods and nanoparticles (HCPT NRs and HCPT NPs) have been investigated in vivo. The results indicate that rodlike nanodrugs exhibit superior antitumor efficacy over that of nanoparticles, however they will also bring much higher in vivo systematic toxicities, which should be fully considered in practice.263