Nebulised amphotericin B-polymethacrylic acid nanoparticle prophylaxis prevents invasive aspergillosis

Nebulised nanoparticle prevents invasive aspergillosis. Aspergillus species are the major life threatening fungal pathogens in transplant patients. They cause severe pneumonia with mortality of > 50%. Preventing infection is therefore being explored. This very low MWt amphotericin B-polymethacrylic acid nanoparticle was given as an aerosol to a transplant immuno-suppression mouse model with life threatening invasive aspergillosis. Protection was associated with > 99% killing of the Aspergillus and a 90% reduction in lung TNF-α related inflammation. Simple and cost-effective pre-exposure prophylaxis prevents invasive lung fungal infections.245