Toxicity studies of coumarin 6-encapsulated polystyrene nanospheres conjugated with peanut agglutinin and poly(N-vinylacetamide) as a colonoscopic imaging agent in rats

The nanobeacon is non-toxic and the no observable adverse effect levels (NOAEL) in oral and intrarectal administrations were estimated to be > 1000 mg/kg/day and > 50 mg/kg/day, respectively, in rats.54