کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10435997 | 911021 | 2015 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Protein transfer-mediated surface engineering to adjuvantate virus-like nanoparticles for enhanced anti-viral immune responses
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
سایر رشته های مهندسی
مهندسی پزشکی
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
Virus-like nanoparticles (VLPs) are used as a platform to produce safe and effective vaccines against viruses, however cross-protection against heterologous viral strains is still difficult to obtain. Herein, we demonstrate a protein transfer method used to modify the surfaces of enveloped influenza VLPs to enhance the breadth and potency of influenza-specific immune responses. A simple incubation of VLPs with purified glycosylphosphatidylinositol-anchored immunostimulatory molecules (GPI-ISMs) results in time and concentration-dependent incorporation of functional ISMs onto VLPs. Further, vaccination with GPI-GM-CSF-protein transferred-VLPs led to enhanced antiviral antibody responses and complete protection against heterologous influenza virus challenge unlike vaccination with unmodified VLPs.156
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nanomedicine: Nanotechnology, Biology and Medicine - Volume 11, Issue 5, July 2015, Pages 1097-1107
Journal: Nanomedicine: Nanotechnology, Biology and Medicine - Volume 11, Issue 5, July 2015, Pages 1097-1107
نویسندگان
Jaina M. Patel, Min-Chul PhD, Vincent F. Vartabedian, Yu-Na PhD, Sara MS, Jae-Min PhD, Hyo-Jick PhD, Satoshi Yamanaka, Nikhil Amaram, Anna Lukacher, Carlo D. PhD, Richard W. PhD, Sang-Moo PhD, Periasamy PhD,