Folic acid-tagged protein nanoemulsions loaded with CORM-2 enhance the survival of mice bearing subcutaneous A20 lymphoma tumors

A novel therapeutic approach using folic acid (FA)-tagged protein nanoemulsions, as targeting carrier, and Carbon-Monoxide Releasing Molecule 2 (CORM-2) was described and discussed. FA-tagged protein nanoemulsions loaded with CORM-2, a hydrophobic anti-proliferative drug, induce a strong antitumor effect and increased the survival of mice bearing subcutaneous A20 lymphoma tumors.77