Magnetic micelles for DNA delivery to rat brains after mild traumatic brain injury

DNA delivery and expression in the rat brain after mTBI. Upper panel shows the experimental design. Induction of mTBI with the help of Lateral Fluid Percussion Instrument (LFPI) is followed by intranasal administration of CPMM-ptd complex and application of magnetic force. Coronal sections of brain in the lower panel summarize the results. mTBI causes blood-brain barrier (BBB) disruption. CPMM-ptd conjugates administered intranasally after mTBI enter the brain via the compromised BBB. Under the magnetic field CPMM-ptd become concentrated in the cortex and hippocampus and red fluorescent protein (RFP, shown in red) is expressed.67