A steroid-mimicking nanomaterial that mediates inhibition of human lung mast cell responses

This study focuses on the utility of strategically functionalized fullerene nanomaterials as a potential alternative therapy for inhaled corticosteroids, specifically in regards to mast cell mediated allergic inflammation. Myo-Inositol modified 70-carbon fullerenes (C70-I) are taken up by mast cells and result in down-regulation of MAPK via DUSP1 induction, similar to inhaled corticosteroids, resulting in significant inhibitions of inflammatory mediator release (degranulation and GM-CSF cytokine release).202