Local hyperthermia treatment of tumors induces CD8+ T cell-mediated resistance against distal and secondary tumors

Mouse primary dermal tumors were heated to 43 °C for 30 min by intratumorally injecting iron oxide nanoparticles and applying an alternating magnetic field. This treatment activated dendritic cells and CD8+ T cells in the draining lymph node and conferred resistance against tumor rechallenge on both the primary tumor side and contralateral side in a CD+ T cell-dependent manner.175