Poly(lactic acid)-poly(ethylene glycol) nanoparticles provide sustained delivery of a Chlamydia trachomatis recombinant MOMP peptide and potentiate systemic adaptive immune responses in mice

Nanoencapsulation of M278, a Chlamydia trachomatis recombinant MOMP (major outer-membrane protein) peptide within PLA-PEG copolymer (PLA-PEG-M278) provided its slow release that potentiated immune responses in BALB/c mice by sustained antigen presentation. Compared to bare M278, enhanced adaptive immune responses were triggered by encapsulated M278 in mice including specific T-cell cytokines and isotype antibodies, along with in vitro serum-mediated inhibition of Chlamydia infectivity of macrophages.183