Gelatin nanostructured lipid carriers-mediated intranasal delivery of basic fibroblast growth factor enhances functional recovery in hemiparkinsonian rats

The gelatin nanostructured lipid carriers efficiently encapsulated exogenous basic fibroblast growth factor and delivered it to the areas of olfactory bulb and striatum via nasal epithelium. The basic fibroblast growth factor not only stimulated the dopaminergic function in surviving neurons but may also play a neuroprotective role, which partially converted the loss of dopaminergic neurons and apomorphine-induced rotations in hemiparkinsonian rats.79