Lipid-polymer nanoparticles encapsulating curcumin for modulating the vascular deposition of breast cancer cells

Tumor cells adhere to the vessel walls and migrate across the endothelium to colonize distant sites. Vascular adhesion molecules, such as ICAM-1 and E-selectin, support the interaction of circulating tumor cells with the inflamed endothelium facilitating cell extravasation. Long circulating nanoparticles loaded with curcumin, a potent anti-inflammatory natural product, can modulate the expression of adhesion molecules on both the circulating tumor cells and the inflamed endothelium thus reducing the likelihood of metastasis formation.122