Targeting of diacerein loaded lipid nanoparticles to intra-articular cartilage using chondroitin sulfate as homing carrier for treatment of osteoarthritis in rats

Concentrations of chondroitin sulfate (ChS) in articular cartilage (μg/mg of wet weight of cartilage), rhein in plasma (μg/ml) and synovial fluid (μg/ml) in animals of different groups. All values are presented as mean ± SD (n = 4; ANOVA); *P = < 0.05, **P = < 0.01 compared to arthritic control for ChS; #P = < 0.05, ##P = < 0.001 compared to drug (dispersed in 0.3% NaCMC) for rhein in plasma and synovial fluid.106