Focused ultrasound delivery of Raman nanoparticles across the blood-brain barrier: Potential for targeting experimental brain tumors

Surface enhanced Raman scattering (SERS) nanoparticles have gained prominence in their potential diagnostic and therapeutic applications in cancer medicine. Focused ultrasound is a novel technique that can enhance the delivery of nanoparticles across the blood-brain barrier. In this study we demonstrate the feasibility of delivering SERS gold nanoparticles to the invasive front of a malignant brain tumor model. In addition, we demonstrate in-vitro uptake of multifunctional SERS gold nanoparticles by glioblastoma cells and the capacity to use these particles for glioblastoma tumor cell labeling in-vivo.83